Pregnancy - Related effects on Tenofovir Pharmacokinetics : 1 A Population Study with 186 women
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چکیده
3 4 Sihem Benaboud a,b , Déborah Hirt , Odile Launay , Emmanuelle Pannier , 5 Ghislaine Firtion , Elisabeth Rey , , Naïm Bouazza a, , Frantz Foissac a, , 6 Hélène Chappuy a,c,g , Saik Urien a, , Jean Marc Tréluyer a, b,c,f 7 8 Affiliations: a Université Paris Descartes, EA3620, Paris, France, b Unité de 9 Recherche clinique Cochin/Necker, AP-HP, Paris, France, c CIC inserm 090, d AP10 HP, Groupe Hospitalier Paris Centre, Service de Gynécologie-Obstétrique, Groupe 11 Hospitalier Paris Centre, Maternité Port Royal, Paris, France, e AP-HP, Groupe 12 Hospitalier Paris Centre, Pôle de Médecine, CIC de Vaccinologie Cochin Pasteur, 13 Paris, France, f Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris 14 Centre, g Hôpital Necker Enfants Malades, Université Paris-Descartes, Paris, France. 15 16 17 Short title: Pregnancy – Tenofovir pharmacokinetics 18 Corresponding author: Sihem Benaboud 19 Unité de Recherche Clinique, Hôpital Tarnier, 89 rue d’Assas, 75006 Paris, 20 [email protected] , tel : +33158413389 Fax : +33158411183 21 Abstract: 190 words, Manuscript: 2,053 words 22 Number of figures: 4, Number of tables: 4, Number of references: 14. 23
منابع مشابه
Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women.
According to the European AIDS Clinical Society, tenofovir disoproxil fumarate can be used in HIV-infected pregnant women if started prior to pregnancy, although no data are available on the pharmacokinetics of tenofovir (TFV) during pregnancy. The aim of this study was to describe TFV pharmacokinetics in HIV-infected women and to evaluate the effect of pregnancy on TFV disposition. Samples wer...
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تاریخ انتشار 2011